Engelsk titel: Is combining metronidazole and alcohol really hazardous?
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Författare:
Fjeld, Hilde
;
Raknes, Guttorm
Email: guttorm.raknes@gmail.com
Språk: Nor
Antal referenser: 20
Dokumenttyp:
Översikt
UI-nummer: 14107322
Sammanfattning
BACKGROUND It is common practice to warn against intake of alcohol (ethanol) when taking metronidazole because of the risk of an effect
similar to disulfiram (Antabuse). In this article we investigate whether such a warning has any real basis.
KNOWLEDGE BASE The article is based on a review of relevant literature retrieved through a search in PubMed. A search was also made in the
WHO’s database on adverse effects.
RESULTS No in-vitro studies, animal models, reports of adverse effects or clinical studies provide any convincing evidence of a disulfiram-like
interaction between ethanol and metronidazole.
INTERPRETATION The warning against simultaneous use of alcohol and metronidazole appear to be based on laboratory experiments and
individual case histories in which the reported reactions are equally likely to have been caused by ethanol alone or by adverse effects of
metronidazole. Recent research does not confirm a clinically relevant interaction between ethanol and metronidazole.