There is no association between the serotonin receptor gene and bipolar I disorder in the Korean
population
Sammanfattning
Objective: Despite the close relationship between the functional polymorphism C(-1019)G
(rs6295) of the serotonergic 1A receptor (5-HT1A) and mood, few studies have investigated the
relationship between rs6295 and bipolar disorder. Aims: In this study, we aimed to investigate
whether rs6295 is associated with clinical prognosis and treatment response in patients with
bipolar I disorder acute manic episodes. Methods : One hundred twenty-eight patients with
bipolar I disorder and one hundred sixty-eight healthy controls were recruited. Associations
between patients with bipolar I disorder and healthy controls were compared. In addition, age at
onset, number of admissions, and treatment response, including response rate, mean changes in
manic symptoms, number of anti-manic agents and the total dosage of mood stabilizers for
acute manic symptoms were compared between the rs6295 GG and CG CC groups in patients
with bipolar I disorder. We conducted a separate subgroup analysis according to gender.
Results : There were no differences in frequency between patients and controls. In patients with
bipolar disorder, clinical prognosis and treatment response were no different between GG and
CG CC groups. However, in a subgroup analysis according to gender, male, but not female,
patients in the GG group had a longer duration of illness and a greater number of both previous
episodes and psychiatric ward admissions than did the GC CC group. Conclusions : Further
studies should investigate the relationship between 5-HT1A polymorphisms and bipolar disorder
in terms of mood episode and gender.