Et kritisk blikk på dokumentasjonen for bruk av (Amoxicillin + Metronidazol) i periodontien
Sammanfattning
The "combination therapy" Metronidazole and Amoxicillin (CT) has gained a reputation as the
correct and effective antibiotic regimen to use as an adjunct to scaling and root planing when treating
periodontal diseases. However, there are very few - if any - good reasons for this reputation. This
article summarizes the scientific documentation behind the clinician''s interest for using CT as an
adjunct to scaling and root planing when treating periodontal diseases. It shows that current literature
of lesser in quality, mostly based on very short studies with insufficient follow-up, insufficient
number of test persons, insufficient study design, general lack of microbiological diagnosis in
decision making, insufficiently explained clinical procedures, and a conflicting view on the use of CT
(and antibiotics in general) with WHO and EU health bodies. Aside from recurrent, aggressive
periodontitis with a microbiological diagnosis of A. actinomycetemcomitans, there is no scientific
support for the use of CT in the treatment of periodontal diseases. Based on existing literature
adequate quality, a clinical flow diagram for decision-making and clinical treatment that involves
antibiotic therapy is presented.