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Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform
Engelsk titel: Optogenetics brings hidden neural mechanisms into the light and could become a future therapy Läs online Författare: Melton Axelsen, Tobias ; Navntoft, Charlotte Amalie Emdal ; Hofman Christiansen, Sören ; Dreyer, Jakob Kisbye ; Balslev Sörensen, Jakob ; Gether, Ulrik ; Woldbye, David Paul Drucker Språk: Dan Antal referenser: 29 Dokumenttyp: Översikt UI-nummer: 15117798

Tidskrift

Ugeskrift for Laeger 2015;177(19)1805-8 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Optogenetics is an emergent technology that combines light-sensitive proteins derived from algae, so-called opsins, with genetics. Viral vectors encoding opsins are injected into selective brain regions whereby specific cell populations can be controlled with high precision light pulses delivered via implanted optical fibres. This review focuses on explaining basic principles of optogenetics and describes important insights into neuropsychiatric mechanisms provided by the technology.