Engelsk titel: The differential effects of green tea on dose-dependent doxorubicin toxicity
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Författare:
Mandziuk, Slawomir
;
Gieroba, Renata
;
Korga, Agnieszka
;
Matysiak, Wlodzimierz
;
Jodlowska-Jedrych, Barbara
;
Burdan, Franciszek
;
Poleszak, Ewa
;
Kowalczyk, Michal
;
Grzycka-Kowalczyk, Luiza
;
Korobowicz, Elzbieta
;
Jozefczyk, Aleksandra
;
Dudka, Jaroslaw
Email: a.korg@interia.pl
Språk: Eng
Antal referenser: 69
Dokumenttyp:
Artikel
UI-nummer: 16023217
Sammanfattning
Background: Doxorubicin (DOX) is an anticancer drug displaying cardiac and hepatic adverse
effects mostly dependent on oxidative stress. Green tea (GT) has been reported to play a protective
role in diseases resulting from oxidative stress.
Objective: The objective of this study was to evaluate if GT protects against DOX-induced oxidative
stress, heart and liver morphological changes, and metabolic disorders.
Methods: Male Wistar rats received intraperitoneal injection of DOX (1.0 or 2.0 mg/kg b.w.) for 7
weeks or concomitantly GT extract soluble in drinking water.
Results: There were multidirectional effects of GT on blood metabolic parameters changed by DOX.
Among all tested biochemical parameters, statistically significant protection of GT against DOX-
induced changes was revealed in case of blood fatty acid-binding protein, brain natriuretic peptide,
and superoxide dismutase.
Conclusion: DOX caused oxidative stress in both organs. It was inhibited by GT in the heart but
remained unchanged in the liver. DOX-induced general toxicity and histopathological changes in the
heart and in the liver were mitigated by GT at a higher dose of DOX and augmented in rats treated
with a lower dose of the drug.