Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise
compared to glibenclamide consumption on type 2 Diabetic rodents
Sammanfattning
Background/objective: The purpose of the present study was to evaluate the effect of fenugreek
seed extract in combination with swimming exercise compared to glibenclamide consumption on type
2 diabetic rats.
Design: The acute toxicity test was carried out to choose the safe doses and identify the toxicity
effects of the fenugreek seed extract. To investigate the hypoglycemic effect of the extract and its
effect in combination with swimming training, 80 Wistar Kyoto male streptozotocin-induced diabetic
rats were divided randomly into eight groups: diabetic control (C); fenugreek seed extract 0.8 g/kg
(F1); fenugreek extract 1.6 g/kg (F2); swimming training (S); swimming training plus fenugreek extract
0.8 g/kg (SF1); swimming training plus fenugreek extract 1.6 g/kg (SF2); glibenclamide (G) and
swimming training plus glibenclamide (SG). The rats were orally administrated with the treatments
once a day with the respective treatment, and the training groups were subjected to swimming
training every day for 60 min. Fasting blood samples were collected to measure fasting blood
glucose, lipid profile, adiponectin, leptin, and insulin concentrations.
Results: The results obtained from acute toxicity study showed no toxicity effect of fenugreek seed
extract on the tested dose. Biochemical analysis showed significant improvements in all of the
groups compared to the control group (p<0.05). Plasma insulin concentration and insulin resistance
(HOMA-IR) was significantly reduced in treated groups compared with the diabetic control group.
Plasma leptin were significantly decreased in treated groups compared with the control group; while
adiponectin had markedly increased (p<0.05).
Conclusion: The findings suggest that fenugreek seed consuming, alongside swimming exercise, has
a strong therapeutic effect on the improvement of diabetic parameters.