Prevalence of neuroleptic-induced movement disorders: an 8-year follow-up study in chronic
schizophrenia inpatients
Engelsk titel: Prevalence of neuroleptic-induced movement disorders: an 8-year follow-up study in chronic
schizophrenia inpatients
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Författare:
Parksepp, Madis
;
Ljubajev, Ulle
;
Täht, Karin
;
Janno, Sven
Email: sven.janno@kliinikum.ee
Språk: Eng
Antal referenser: 22
Dokumenttyp:
Artikel
UI-nummer: 16113487
Sammanfattning
Background: Atypical antipsychotic drug use by schizophrenia patients in Estonia increased
from 32% in 2004 to 61% in 2009.
Aims: To assess the prevalence of neuroleptic-induced movement disorders in the Estonian
institutionalized population of schizophrenia patients twice over a period of eight years, before and
after introduction of atypical antipsychotic drugs using DSM-IV criteria.
Methods: DSM-IV criteria and specific rating scales were used to evaluate the prevalence of
neuroleptic-induced movement disorders among 72 patients who participated in the study in 2009
compared to 99 patients who participated in 2001.
Results: Despite increased use of atypical antipsychotics in the study population (up to 30% from
20%), the proportion of movement disorder-free population remained the same over 8 years - 38.9%
in 2001 versus 38.4% in 2009. There were significant intra-individual fluctuations. Use of a typical
antipsychotic resulted in an almost seven times higher risk of tardive dyskinesia after 8 years.
Doses of antipsychotic drugs had no effect on the severity of neuroleptic-induced movement
disorders.
Conclusions: Unfortunately, in 18% of patients the switch of medication from typical to atypical did not
change the overall prevalence of neuroleptic-induced movement disorders in the group. The long-
term benefit of atypical antipsychotics requires further research in patients who are treated with
antipsychotics for years.