Engelsk titel: Hereditary haemochromatosis through 150 years
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Författare:
Ulvik, Rune Johan
Email: rune.ulvik@uib.no
Språk: Nor
Antal referenser: 37
Dokumenttyp:
Artikel
UI-nummer: 17017245
Sammanfattning
Hereditary haemochromatosis is a disorder of abnormal iron metabolism which causes increased absorption and pathological iron deposition in the liver and
other organs, leading to disease. The first known case report was presented in 1865 by the French doctor Trousseau, who described a new syndrome involving
diabetes, pigmented liver cirrhosis and bronze-coloured skin, later referred to as «bronze diabetes».
In 1889 the German doctor von Recklinghausen demonstrated that the liver contains iron, and because bleeding was considered to be the cause, he called the
pigment «haemochromatosis». The link between iron deposition, diabetes and liver cirrhosis was still unknown.
In his groundbreaking 1935 book entitled Haemochromatosis, the English doctor Sheldon provided a retrospective review of 311 patient case reports and put
forward the idea that haemochromatosis was a congenital metabolic disorder.