An Okinawan-based Nordic diet improves anthropometry, metabolic control, and health-related quality of life in Scandinavian patients with type 2 diabetes: a pilot trial
Engelsk titel: An Okinawan-based Nordic diet improves anthropometry, metabolic control, and health-related quality of life in Scandinavian patients with type 2 diabetes: a pilot trial
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Författare:
Darwiche, Gassan
;
Höglund, Peter
;
Roth, Bodil
;
Larsson, Ewa
;
Sjöberg, Trygve
;
Wohlfart, Björn
;
Steen, Stig
;
Ohlsson, Bodil
Email: ghassan.darwiche@med.lu.se
Språk: Eng
Antal referenser: 55
Dokumenttyp:
Artikel
UI-nummer: 17050032
Sammanfattning
Background: Our hypothesis was that a modified diet would improve blood glucose control with beneficial
impact on weight management and overall health in established diabetes.
Objective: This prospective interventional study investigated the clinical effect of an Okinawan-based Nordic
diet on anthropometry, metabolic control, and health-related quality of life (HRQoL) in Scandinavian type 2
diabetes patients.
Design: Food was prepared and delivered to 30 type 2 diabetes patients. Clinical information along with data
on HRQoL, blood samples, and urine samples were collected during 12 weeks of diet interventions, with
follow-up 16 weeks after diet completion.
Results: After 12 weeks of dietary intervention, a reduction in body weight (7%) (p<0.001), body mass index
(p<0.001), and waist circumference (7.0 cm) (p<0.001) was seen. Improved levels of proinsulin (p=0.005),
insulin (p=0.011), and fasting plasma glucose (p<0.001) were found already after 2 weeks; these improved
levels remained after 12 weeks when lowered levels of C-peptide (p=0.015), triglycerides (p=0.009), total
cholesterol (p0.001), and low-density lipoprotein-cholesterol (p0.041) were also observed. Insulin
resistance homeostasis model assessment for insulin resistance was lowered throughout the study, with a 20%
reduction in hemoglobin A1c levels (p<0.001) at week 12, despite reduced anti-diabetes treatment. Lowered
systolic blood pressure (9.6 mmHg) (p<0.001), diastolic blood pressure (2.7 mmHg) (p<0.001), and heart and
respiratory rates (p<0.001) were accompanied by decreased cortisol levels (p=0.015) and improvement in
HRQoL. At follow-up, increased levels of high-density lipoprotein-cholesterol were found (p0.003).
Conclusion: This interventional study demonstrates a considerable improvement of anthropometric and
metabolic parameters and HRQoL in Scandinavian type 2 diabetes patients when introducing a modified
Okinawan-based Nordic diet, independently of exercise or other interventions. Through these dietary
changes, anti-diabetes treatment could be decreased or cancelled.
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