Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants
Engelsk titel: Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants
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Författare:
Blakstad, Elin W
;
Moltu, Sissel J
;
Nakstad, Britt
;
Veieröd, Marit B
;
Strömmen, Kenneth
;
Júlíusson, Petur B
;
Almaas, Astrid N
;
Rönnestad, Arild E
;
Braekke, Kristin
;
Drevon,Christian A
;
Iversen, Per O
Email: e.w.blakstad@medisin.uio.no
Språk: Eng
Antal referenser: 41
Dokumenttyp:
RCT
UI-nummer: 17070041
Sammanfattning
Background: Adequate nutrient supply is essential for optimal postnatal growth in very low birth weight
(VLBW, birth weight<1,500 g) infants. Early growth may influence the risk of metabolic syndrome later in life.
Objective: To evaluate growth and blood metabolic markers (adiponectin, leptin, and insulin-like growth
factor-1 (IGF-1)) in VLBW infants participating in a randomized nutritional intervention study.
Design: Fifty VLBW infants were randomized to an enhanced nutrient supply or a standard nutrient supply.
Thirty-seven infants were evaluated with growth measurements until 2 years corrected age (CA). Metabolic
markers were measured at birth and 5 months CA.
Results: Weight gain and head growth were different in the two groups from birth to 2 years CA (weight gain:
pinteraction=0.006; head growth: pinteraction=0.002). The intervention group improved their growth z-scores
after birth, whereas the control group had a pronounced decline, followed by an increase and caught up
with the intervention group after discharge. At 5 months CA, adiponectin concentrations were higher in
the intervention group and correlated with weight gain before term (r=0.35) and nutrient supply
(0.355