Engelsk titel: Inflammation and atherosclerosis – last piece of the puzzle has fallen into place
Läs online
Författare:
Jonasson, Lena
;
Hansson, Göran K
Email: lena.jonasson@liu.se
Språk: Swe
Antal referenser: 7
Dokumenttyp:
Artikel
UI-nummer: 18010126
Sammanfattning
Inflammation is a major component of atherosclerotic lesions and inflammatory biomarkers can be used to predict cardiovascular disease. Still, it has been unclear whether inflammation is a driving force in atherosclerosis, or merely an epiphenomenon. The recently published results of the CANTOS trial shows that treatment with canacinumab, a monoclonal antibody to the proinflammatory cytokine interleukin-1β, led to a significantly lower rate of recurrent cardiovascular events, compared to placebo. Thus, it establishes beyond doubt that inflammation is a treatable pathogenetic mechanism in atherosclerosis.