Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study
Engelsk titel: Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study
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Författare:
Mikulic, Suzan Kudlek
;
Mihaljevic-Peles, Alma
;
Sagud, Marina
;
Janovic, Maja Bajs
;
Ganoci, Lana
;
Grubisin, Jasmina
;
Rojnic, Martina Kuzman
;
Cusa, Bjanka Vuksan
;
Bradas, Zoran
;
Božina, Nada
Email: mbajs@yahoo.com
Språk: Eng
Antal referenser: 59
Dokumenttyp:
Artikel
UI-nummer: 18020205
Sammanfattning
Antipsychotics have been the mainstay of the treatment of schizophrenia, and their potential role in
neuroprotection could be related to brain-derived neurotrophic factor (BDNF). So far different effects
on both serum and plasma levels of BDNF were reported related to the various antipsychotic treatments.
Aim of this study was to investigate the influence of olanzapine or risperidone on both plasma
and serum levels of BDNF in patients with acute schizophrenia. For 50 participants with acute episode
of schizophrenia both plasma and serum BDNF, along with the Positive and Negative Syndrome Scale
(PANSS) and the Clinical Global Impression scale, were assessed pretreatment and post treatment –
after 6 weeks of either risperidone or olanzapine. Results show that a weak correlation between pretreatment
plasma and serum levels of BNDF was found no longer significant after 6 weeks of treatment.
Antipsychotics, olanzapine and risperidone showed no significant effect on post treatment
plasma and serum levels of BDNF. Pretreatment plasma level of BDNF and PANSS positive subscale
were positively correlated. Post treatment serum level of BDNF and Clinical Global Impression were
negatively correlated. In conclusion, plasma and serum BDNF levels could be different markers to some
extent with regard to clinical symptoms, response to therapy and outcome. The interrelation between
serum and plasma BDNF should be established in further studies.