Oral mikrobiolog i mikrobiom-eran – när, hur och varför utförs mikrobiologisk diagnostik?
Engelsk titel: Oral microbiology in the microbiome era – when, how and why is microbiological diagnostics performed?
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Författare:
Välimaa, Hanna
;
Fröding, Inga
;
Frandsen Lau, Ellen
Email: hannamari.valimaa@helsinki.fi
Språk: Swe
Antal referenser: 37
Dokumenttyp:
Artikel
UI-nummer: 19050263
Sammanfattning
Knowledge concerning the oral microbiota has increased greatly during the past decade, after the introduction of high-throughput sequencing technologies. These culture-independent technologies have enabled the detection of the as yet uncultured bacterial species that make up about half of
the 700 species identified in the oral microbiome. Similarly, the oral microbiome has been shown to be much more diverse than previously expected.
Currently, studies are underway to clarify the differences between the microbiome in health and disease with regard to both the species involved and
the functional properties of the microbiome. The implications for disease management and diagnostics still remain undetermined.
Culture is still the preferred diagnostic method both for bacterial and fungal infections. The benefit of using culture is that it enables identification of
multiple species and antimicrobial susceptibility testing. Nucleic acid detection methods have become increasingly available for the detection of a
number of suspected periodontal pathogens, as well as for diagnostics of viral infections. Microbiological diagnostics are not routinely needed but it may
be helpful in complicated or refractory infections and in differential diagnostics.