Engelsk titel: Localized lipohypertrophy during growth hormone therapy
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Författare:
Mersebach H
;
Feldt-Rasmussen UF
Språk: Dan
Antal referenser: 8
Dokumenttyp:
Fallbeskrivning
UI-nummer: 02041224
Sammanfattning
Accumulation of subcutaneous fat is described in a 51-year-old woman with panhypopituitarism treated on all insufficient pituitary axes, including growth hormone (GH). Malnutrition and alcoholic liver disease caused reduced synthesis of hepatic insulin-like growth factor I (IGF-I), and the function of IGF-I as biochemical marker of the GH effect was compromised. Peripheral levels of GH and IGF-I in tissues may have reached supra physiological levels and induced localised lipohypertrophy. Adjustment of GH treatment should not rest in all cases on IGF-I alone, but also depend on the clinical effect. Adjustment should follow suspected adverse events, such as lipohypertrophy, which is, however, an unusual complication of GH therapy.