Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma
advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical
trial
Sammanfattning
Introduction: Diabetes mellitus characterized by hyperglycemia could increase oxidative stress
and formation of advanced glycated end-products (AGEs), which contribute to diabetic complications.
The purpose of this study was to assess the effect of pomegranate juice (PJ) containing natural
antioxidant on lipid peroxidation and plasma AGEs in patients with type 2 diabetes (T2D).
Materials and methods: In a randomized, double-blind, placebo-controlled trial, 44 patients (age
range 56±6.8 years), T2D were randomly assigned to one of two groups: group A (PJ, n=22) and group
B (Placebo, n=22). At the baseline and the end of 12-week intervention, biochemical markers
including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy
methyl lysine (CML) and pentosidine were assayed.
Results: At baseline, there were no significant differences in plasma total antioxidant capacity (TAC)
levels between the two groups, but malondialdehyde (MDA) decreased levels were significantly
different (P<0.001). After 12 weeks of intervention, TAC increased (P<0.05) and MDA decreased
(P<0.01) in the PJ group when compared with the placebo group. However, no significant differences
were observed in plasma concentration of CML and pentosidine between the two groups.
Conclusions: The study showed that PJ decreases lipid peroxidation. Therefore, PJ consumption may
delay onset of T2D complications related to oxidative stress