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Medikamentel behandling af kemoterapiinduceret kvalme og opkastning
Engelsk titel: Medical treatment of chemotherapy-induced nausea and vomiting Läs online Författare: Herrstedt J Språk: Dan Antal referenser: 40 Dokumenttyp: Översikt UI-nummer: 07031029

Tidskrift

Ugeskrift for Laeger 2007;169(9)799-805 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Patients consider nausea and vomiting among the worst side effects of chemotherapy. This paper reviews the development of antiemetics during the past 12 years, focusing on the neurokinin (NK)1 -receptor antagonist, aprepitant, and the new 5-HT3 -receptor antagonist palonosetron. Evidence-based recommendations for prophylaxis of chemotherapy-induced nausea and vomiting are given. Antiemetics are effective in prevention of vomiting, but less effective against nausea. Therefore studies with potential new antiemetics, such as olanzapine and ghrelin are awaited with suspense.