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Cannabis og cannabinoider som legemidler
Engelsk titel: Cannabis and cannabinoids as drugs Läs online Författare: Khiabani HZ ; Mörland J Språk: Nor Antal referenser: 55 Dokumenttyp: Översikt UI-nummer: 07031066

Tidskrift

Tidsskrift for Den Norske Laegeforening 2007;127(5)579-82 ISSN 0029-2001 E-ISSN 0807-7096 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

BACKGROUND : Cannabis has been used throughout human history. Delta (9)-tetrahydrocannabinol (THC) is the primary psychoactive component of cannabis. THC metabolises to 11-OH-THC and further to THC-acid, which is an inactive metabolite. We present an overview of the pharmacokinetics and pharmacodynamics of cannabinoids. MATERIAL AND METHOD : This article is based on selected literature with an emphasis on the pharmacodynamics of cannabinoids. RESULTS AND INTERPRETATION : It has been demonstrated that mammalian tissues express cannabinoid receptors (CB1, CB2 and most probably CB3) and endogenous ligands for these. Knowledge of these receptors has lead to the development of components that stimulate (CB-agonists) or block their function (CB-antagonists). This opens up for the study of any potential therapeutic effects of cannabinoids. Research on a possible therapeutic potential of cannabinoids should however not overshadow the well-documented negative effects of cannabis; i.e. impaired cognitive functions, intoxication and an increased risk for development of psychosis and psychotic symptoms.