Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus
Engelsk titel: Effect of incretin hormones GIP and GLP-1 for the pathogenesis of type 2 diabetes mellitus
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Författare:
Vilsböll T
;
Knop FK
Email: t.vilsboll@dadlnet.dk
Språk: Dan
Antal referenser: 40
Dokumenttyp:
Översikt
UI-nummer: 07061727
Sammanfattning
Oral administration of glucose stimulates insulin secretion to a greater extent than does glucose administered as an isoglycaemic intravenous glucose infusion. This phenomenon is called the incretin effect and is caused by the two incretin hormones GIP and GLP-1. In patients with type 2 diabetes, the incretin effect is impaired. The mechanisms of the impaired incretin effect have been found to involve reduced secretion of GLP-1 and a severely impaired effect of GIP. It is currently unknown whether these defects are consequences of the diabetic state or primary pathogenetic factors.