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Medical advice does not necessarily concur with what the patient wants. Difference in opinion between the physician and the patient may be due to poor communication, but also different goals and views of health. This is a general problem. This article focuses on the basis for cooperation between doctor and patient with regard to use of anti-psychotic drugs. The question is whether the concept of compliance recognizes and takes in the complexity connected to use of anti-psychotic drugs. The concept of concordance, on the other hand, focuses consultation and cooperation. The question is whether this is feasible with regard to treatment of psychosis. Compliance depends on what the patients actually thinks or believes about the medication regardless the opinions are in fact true or not. We argue that patient opinions and experience will be crucial in understanding how patients choose to act. Consequently, we need a concept that emphasizes treatment goals and intentions of the patients. This also necessitates a need to investigate patient attitudes about anti-psychotic drugs

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