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Arvelig brystkraeft: behandling og forebyggelse
Engelsk titel: Hereditary breast cancer: treatment and prevention Läs online Författare: Ejlertsen B ; Gerdes AM Språk: Dan Antal referenser: 10 Dokumenttyp: Artikel UI-nummer: 07101291

Tidskrift

Ugeskrift for Laeger 2007;169(36)2972-5 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

In general, the treatment of early breast cancer is guided by the results from large randomised trials. The same does not apply to patients who carry BRCA1/2 mutations. The selection of loco-regional therapies might change according to BRCA1/2 mutation status. In order to reduce the risk of secondary breast and ovarian cancer, these patients may also be offered prophylactic oophorectomy. The possible impact of BRCA1/2 mutations on the efficacy of medical therapies has recently attained much interest, alongside the development of targeted therapies against BRCA1/2 associated cancers.