Ambulant kontinuerlig registrering af pH og impedans i ösofagus. Erfaring fra de förste 100 danske patienter
Engelsk titel: Multiple intraluminal impedance and pH measurement in the esophagus. Experience with the first 100 Danish patients
Läs online
Författare:
Dalby K
;
Marköw S
Email: kasperdalby@yahoo.com
Språk: Dan
Antal referenser: 16
Dokumenttyp:
Artikel
UI-nummer: 07101559
Sammanfattning
Introduction: Symptoms of gastroesophageal reflux are common in the Western world. Multiple Intraluminal Impedance (MII) measurement in the esophagus is a new diagnostic method for the evaluation of patients with suspected gastroesophageal reflux disease (GERD). Multiple pairs of impedance electrodes on a pH probe enable the detection of retrograde bolus movement in the esophagus. The acidity of the bolus can be detected by the pH probe. Materials and methods: 100 patients referred to our motility laboratory with symptoms of GERD were monitored with MII for 24 hours. Impedance was measured at 6 levels (3, 5, 7,9,15 and 17 cm above LES) and pH was measured 5 cm above the manometrically defined LES. The total number and the number of acid and non-acid reflux episodes were detected by the combination of MII and pH. Results: 97 of the 100 patients completed at least 20 hours of registration. 9 of the 100 investigated patients exhibited pathological volume reflux despite a normal index for acid reflux. 46 of the 97 investigated patients had a normal reflux index. In 9 (20%) patients pathological volume reflux was found by means of MII. Conclusion: Combined MII and pH measurements provide new insight into the pathophysiology of GERD. It enables detection of volume reflux and a division into acid and non-acid reflux episodes. In the present study we found that 20% of patients with a normal reflux index had volume reflux.