Graves' sjukdom vid graviditet ger risk för barnet. TSH-receptorantikroppar hos kvinnan kan ge fetal och neonatal tyreotoxikos
Engelsk titel: Graves disease in pregnancy a risk for the child. Maternal TSH receptor antibodies can cause fetal and neonatal thyrotoxicosis
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Författare:
Roos M
;
Sjöberg O
;
Axelsson O
;
Karlsson FA
Email: anders.karlsson@medsci.uu.se
Språk: Swe
Antal referenser: 20
Dokumenttyp:
Fallbeskrivning
UI-nummer: 08011160
Sammanfattning
Maternal Graves' disease during pregnancy is a condition that may be complicated by fetal and neonatal thyreotoxicosis. The mechanism of these complications is a transplacental passage of stimulating TSH-receptor antibodies from the mother to the fetus. In this article two case reports are presented as an illustration of the clinical course of Graves' disease during pregnancy. The level of TSH-receptor antibodies (TRAK) in the serum of the pregnant woman is a predictor of the risk of fetal and neonatal thyreotoxicosis. In recent years, new methods for determination of TRAK have been introduced. We have used all these methods and compared the data obtained with those from an earlier technique. Values of TRAK during pregnancy corre¬sponding to a high risk of fetal and neonatal effects are presented.