Neisseria meningitidis. Lipopolysakkariders patofysiologiske rolle ved meningokoksygdom og septisk shock
Engelsk titel: Neisseria meningitidis. The pathophysiological role of lipopolysaccharides in association with meningococcal disease and septic shock
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Författare:
Pedersen DS
;
Pedersen M
;
Penkowa M
Email: mieped@stud.ku.dk
Språk: Dan
Antal referenser: 40
Dokumenttyp:
Översikt
UI-nummer: 08021370
Sammanfattning
A major pro-inflammatory and toxic component of N. meningitidis is lipopolysaccharide (LPS). LPS contributes to severe symptoms of meningococcal disease, septic shock and severe coagulopathy, in part by increasing pro-inflammatory mechanisms and reactive oxygen species. Recent technologies have increased the likelihood of developing an anti-meningococcal immunization strategy based upon the virulence of LPS which may lead to a vaccination against this important pathogen including serogroup B disease. This review summarizes recent findings that may provide a safe, effective prophylaxis and therapy.