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Mannanbindende lectin og mannanbindende lectin-associeret serinprotease-2
Engelsk titel: Mannan-binding lectin and MBL-associated serine protease-2 Läs online Författare: Jörgensen J ; Ytting H ; Steffensen RM ; Nielsen HJ Språk: Dan Antal referenser: 35 Dokumenttyp: Översikt UI-nummer: 08051940

Tidskrift

Ugeskrift for Laeger 2008;170(17)1445-8 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

In Denmark approximately 3,600 patients are diagnosed with colorectal cancer (CRC) every year. 75-80% of patients may undergo intended curative resection, but the disease recurs in about 40% within five years and the prognosis is poor. Hence, there is a need for biological markers that could be used for detection, evaluation of prognosis, therapy selection and monitoring. The serum proteins of the innate immune system mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are novel biomarkers under validation in CRC. Low preoperative MBL levels are predictive of pneumonia which subsequently is associated with poor survival. High MASP-2 levels predict recurrence and poor survival.