Engelsk titel: The Na+,K+ pump continues to cause surprise
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Författare:
Vilsen B
Email: bv@fi.au.dk
Språk: Dan
Antal referenser: 4
Dokumenttyp:
Artikel
UI-nummer: 08051108
Sammanfattning
This article provides an overview of news about the Na+,K+ pump, an indispensable enzyme whose protein structure has been described in a recent article in Nature, 50 years after its discovery. In combination with mutational analysis, the structure reveals the binding pocket for the K + ions and the regulation of Na+ transport by a strategically located C-terminus of the protein. Focus is also on the pathophysiology of two neurological disorders, familial hemiplegic migraine and rapid-onset dystonia-parkinsonism, recently shown to be caused by mutations in the Na+,K+-ATPase.