S100B för diagnostik och prediktion av sequelae efter lätt skallskada. Studier visar delvis motsägande resultat
Engelsk titel: S100B for diagnosis and prognosis of sequelae following minor head injury. Contradictory results according to studies
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Författare:
Stålnacke BM
;
Sojka P
Email: brittmarie.stalnacke@rehabmed.umu.se
Språk: Swe
Antal referenser: 72
Dokumenttyp:
Översikt
UI-nummer: 08061262
Sammanfattning
S-100B is a protein that leaks from injured brain tissue into the cerebrospinal fluid and blood, where it can be traced and quantified. Accordingly, it may serve as a 'biochemical marker of brain tissue injury'. The aim of this paper is to survey studies that investigate symptoms, impairments, disabilities and life satisfaction exhibited by patients with mild traumatic brain injury long after the trauma (>3 months) in relation to blood concentrations of S-100B in acute stage. A PubMed search and further analysis revealed 15 papers corresponding to these criteria. The results of these papers conflict and no clear-cut conclusion can be drawn with respect to clinical use of S-100B as a predictor for late sequelae of mild traumatic brain injury. New studies that adequately take into account biological characteristics of S-100B as a 'marker of brain tissue injury' are needed.