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Genetisk variation i alkoholdehydrogenase, alkoholdrikkevaner og alkoholisme - sekundaerpublikation
Engelsk titel: Genetic variations in alcohol dehydrogenase, drinking habits and alcoholism - secondary publication Läs online Författare: Rasmussen S ; Tybjaerg-Hansen A ; Grönbaek M ; Tolstrup JS ; Nordestgaard BG Språk: Dan Antal referenser: 8 Dokumenttyp: Artikel UI-nummer: 08091826

Tidskrift

Ugeskrift for Laeger 2008;170(35)2672-5 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Alcohol is degraded primarily by alcohol dehydrogenase (ADH), and genetic variation that affects the rate of alcohol degradation is found in ADH1B and ADH1C. By genotyping 9,080 white men and women from the general population, we found that men and women with ADH1B slow versus fast alcohol degradation drank approximately 30% more alcohol per week and had a higher risk of everyday and heavy drinking, and of alcoholism. Individuals with ADH1C slow versus fast alcohol degradation had a higher risk of heavy drinking.