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RESULTS AND INTERPRETATION : Transethmoid meningoencephalocele, pituitary conditions and the need for biopsy from the cavernous sinus are presented as suitable indications for transnasal endoscopic skull base procedures. From an anatomical point of view, the skull base is situated between the orbit, the ear and the paranasal sinuses on one side and the brain on the other side. Several specialties are therefore involved in skull base surgery, and interdisciplinary cooperation is important. Computer-assisted surgical instruments and navigation systems based on digital imaging enable an improved perioperative orientation and thereby improves the safety of skull base surgery. Endoscopic surgery at the skull base may contribute to reduce surgical morbidity and hospitalization and thereby has a health economic potential. MATERIAL AND METHODS : An overview is given of transnasal endoscopic skull base surgery, based on literature retrieved from PubMed and illustrated by three patients operated at the University Hospital of Northern Norway. INTRODUCTION : Skull base surgery is targeted to diseases in the posterior, lateral or anterior skull base. Development of endoscopic paranasal sinus surgery has contributed to expand the indications for transnasal surgery at the anterior skull base. Patients do not have visible scars and have less postoperative pain after endoscopic surgery and a decreased postoperative morbidity in general results in a shorter hospital stay.

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