Abatacept til behandling af reumatoid artritis
Engelsk titel: Abatacept in the treatment of active rheumatoid arthritis
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Författare:
Nielsen H
;
Hansen A
Email: hennie04@heh.regionh.dk
Språk: Dan
Antal referenser: 10
Dokumenttyp:
Artikel
UI-nummer: 09021910
Sammanfattning
Abatacept (CTLA4Ig) is a human fusion protein which consists of a cytotoxic lymphocytic-associated type 4 antigen which is bound to the Fc part of the IgG1. Abatacept binds to CD80/CD86 on antigen-presenting cells thus blocking the co-stimulatory signal to the naïve T cells and interfering with a central inflammatory rheumatoid arthritis signal pathway.