Ny typning av hepatit B-virus ger bättre övervakning av smittspridning. Prospektiv molekylär typning visar ökad sexuell spridning
Sammanfattning
Since 2004 154 acute hepatitis B cases in Stockholm have been prospectively typed into subgenotypes and subtypes. Most strains, 66%, belong
ed to genotype D, and 12% respectively 10% belonged to genotypes C and A. Males were more often than females infected with A2/adw2, prevalent among homosexual men, and with C2/adr, common in Thailand. Inversely, females were more often than males infected with D1/ayw2, common around the Mediterranean and in the Middle East. Injecting drug use (IDU) was earlier the most important transmission route of hepatitis B in Sweden, but only 43% were infected with the IDU associated strain D3/ayw3, and 45% of these were females indicating heterosexual transmission. This first study, where typing also included subgenotypes and subtypes, has improved the revelation of transmission routes, where interviewing may be delicate, and has shown that sexual spread of HBV now is as important as IDU in Stockholm.