Engelsk titel: Stem cell harvesting after plerixafor treatment
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Författare:
Boye Hansen P
;
Gaarsdal E
Email: peboha01@heh.regionh.dk
Språk: Dan
Antal referenser: 5
Dokumenttyp:
Fallbeskrivning
UI-nummer: 09111944
Sammanfattning
A 66-year-old male with mantle cell lymphoma was treated with chemotherapy before consolidation with autologous stem cell transplantation. Despite three series of treatment with chemotherapy and stimulation with granulocyte colony-stimulating factor (filgrastim), it was not possible to mobilize hematopoietic stem cells for leukapheresis. After permission from the Danish Medicines Agency, a new stem cell factor, plerixafor, which is a direct antagonist of a surface receptor on stem cells was used. After five days of pre-treatment with filgrastim and two days of treatment with plerixafor, it was possible to harvest a sufficient number of stem cells for transplantation.