Mätning av leverelasticitet kan differentiera hög- och låggradig fibros. Ny metod kan minska behovet av leverbiopsi vid kronisk hepatit C
Engelsk titel: Measurement of liver elasticity can differentiate high and low grade fibrosis. New method can reduce the need of liver biopsy in chronic hepatitis C
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Författare:
Weilan O
;
Wejdmark A
Email: ola.weiland@ki.se
Språk: Swe
Antal referenser: 15
Dokumenttyp:
Artikel
UI-nummer: 09121113
Sammanfattning
Liver biopsy is standard for evaluation of liver fibrosis but non-invasive methods are used more and more. Patients with chronic hepatitis C who had done a liver biopsy within 2 years from measuring their liver elasticity were retrospectively studied at the Division of Infectious Diseases at the Karolinska University Hospital. Low-and high grade fibrosis was defined as fibrosis stage F0-F2 and F3-F4, respectively. GUCI-score was determined with the use of ASAT, INR and platelet levels.Totally 62 patients with chronic hepatitis C were included. Measuring of liver elasticity with Fibroscan could differentiate advanced from non-advanced liver fibrosis with high statistical significance, p < 0.001, and can replace liver biopsy for fibrosis evaluation in the majority of patients with chronic hepatitis C.