Lovande metod för utredning och behandling av infertilitet. Spermiekromatinanalys - bra markör för manlig infertilitet
Engelsk titel: Promising method for investigation and treatment of infertility. Sperm chromatin analysis - useful marker for male infertility
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Författare:
Giwercman, Aleksander
;
Bungum, Leif
;
Bungum, Mona
Email: aleksander.giwercman@med.lu.se
Språk: Swe
Antal referenser: 19
Dokumenttyp:
Översikt
UI-nummer: 10081554
Sammanfattning
Infertility affects 15% of all couples and although it in 50% of the cases is related to aberrations in semen quality, the value of standard semen parameters in prediction of fertility in vivo and choice of proper method for assisted reproduction is limited.
Sperm DNA Fragmentation Index (DFI) as assessed by the flow cytometric Sperm Chromatine Structure Assay can be used for evaluation of sperm chromatin integrity. The biological background for abnormal DFI is not completely known, but clinical data show that DFI above 30% is associated with very low chance for achieving pregnancy in natural way or by insemination, but not in vitro. Already when the DFI is above 20%, the chance of natural pregnancy may be reduced, despite other sperm parameters being normal. Thus this method may explain a significant proportion of cases of unexplained infertility and be used for counselling regarding the need of in vitro fertilisation.