Ufraktioneret og lavmolekylaert heparin ved akutte koronare syndromer - en gennemgang af et Cochrane-review
Engelsk titel: Unfractionated heparin and low molecular weight heparin for acute coronary syndromes - assessment of a Cochrane review
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Författare:
Husted, Steen Elkjaer
;
Kraemmer Nielsen, Hans
Email: steehust@rm.dk
Språk: Dan
Antal referenser: 10
Dokumenttyp:
Översikt
UI-nummer: 10091746
Sammanfattning
In aspirin-treated patients with acute coronary syndromes without ST-segment elevation unfractionated heparin (UFH) or low molecular weight heparin (LMWH) treatment < 7 days significantly reduce the risk of acute myocardial infarction (AMI), and LMWH furthermore reduces revascularisation. There is a non-significant effect on mortality compared with placebo and an insignificantly increased risk of haemorrhaglic complications. No net clinical benefit of LMWH was found compared to UHF, but LMWH has pharmacokinetic advantages. The optimal duration of heparin treatment remains controversial.