Engelsk titel: The effect of aldosterone on renal potassium excretion
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Författare:
Winther, Signe Abitz
;
Egfjord, Martin
Email: abitz@stud.ku.dk
Språk: Dan
Antal referenser: 20
Dokumenttyp:
Artikel
UI-nummer: 11011520
Sammanfattning
Recent studies have shown expression of the following regulatory WNK kinases in the kidney: the full-length WNK1 (L-WNK1), the shorter kidney specific WNK1 transcript (KS-WNK1), formed by alternative splicing, and WNK4. A activates expression of KS-WNK1 and inhibits WNK4 via SGK1 - both leading to stimulation of ENaC and activation of ROMK, and increased potassium excretion (figure 1). Thus, further characterization of the WNK system may lead to elucidation of the dual anti-natriuretic and kaliuretic effects of A, in situations where only activation of one of these effects is needed.