Screening for tuberkuloseinfektion för behandling med biologiske laegemidler
Engelsk titel: Screening for tuberculosis infection prior to treatment with biological terapies
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Författare:
Ravn, Pernille
Email: pravn@dadlnet.dk
Språk: Dan
Antal referenser: 20
Dokumenttyp:
Artikel
UI-nummer: 11041032
Sammanfattning
Tumour necrosis factor antagonists (anti-TNFa) have become an invaluable treatment against chronic inflammatory diseases. Individuals treated with anti-TNFa have more than a fourfold increased risk of tuberculosis (TB) reactivation depending on the clinical setting and the TNF-antagonist used. All candidates for anti-TNFa treatment in Denmark should be evaluated for possible latent TB using history of exposure, chest X-ray and an interferon-? release assay. Preventive chemotherapy is recommended for all individuals with latent TB infection before initiation of anti-TNFa as it is expected to reduce the risk of progression to active TB.