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Hyperfibrinolyse som årsag til blödning og öget mortalitet hos traumepatienter
Engelsk titel: Hyperfibrinolysis as the cause of haemorrhage and increased mortality in trauma patients Läs online Författare: Wikkelsö, Anne Juul ; Afshari, Arash ; Stensballe, Jakob ; Johansson, Pär I Språk: Dan Antal referenser: 19 Dokumenttyp: Artikel UI-nummer: 11051238

Tidskrift

Ugeskrift for Laeger 2011;173(18)1284-7 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Trauma-associated coagulopathies are at times present upon arrival at the emergency department. Hyperfibrinolysis is a condition in which the natural ability to dissolve blood clots is pathologically enhanced. It is present in 2-8% of trauma patients and associated with shock and increased mortality. Hyperfibrinolysis is easily detected by thromboelastography. The condition is treated with antifibrinolytics such as tranexamic acid - where as transfusion with blood products is inefficient. This article explores the mechanisms and diagnostics of hyperfibrinolysis in trauma patients and the relevant treatment options.