Danger-signaler og inflammasomer ved autoinflammatoriske og autoimmune sygdomme
Engelsk titel: Danger signals and inflammasomes in autoinflammatory and autoimmune diseases
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Författare:
Bendtzen, Klaus
Email: klausben@me.com
Språk: Dan
Antal referenser: 20
Dokumenttyp:
Artikel
UI-nummer: 11091959
Sammanfattning
Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ?-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1?, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.