Makrolidresistens hos Mycoplasma pneumoniae ved recidiv og langvarigt sygeforlöb
Engelsk titel: Macrolide resistance in Mycoplasma pneumoniae by recurrence and extended illness
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Författare:
Uldum, Sören
;
Amberg, Paul
;
Skov Jensen, Jörgen
Email: su@ssi.dk
Språk: Dan
Antal referenser: 5
Dokumenttyp:
Fallbeskrivning
UI-nummer: 12031802
Sammanfattning
A 36 year-old female with a Mycoplasma pneumoniae (MP) infection was treated with azithromycin. She recovered transitory, but experienced a relapse a few days later. After ten days she visited her general practitioner again; she was tired and weakened, had a debilitating dry cough and a weight loss of 6 kg. A throat swab was positive for MP by a polymerase chain reaction (PCR). It was investigated by sequencing and a mutation corresponding to a A2063G transition in domain V of the 23S rRNA known to be associated with macrolide resistance was detected. Twenty-two days later, MP could still be detected by PCR on a nasopharyngeal secretion.