Sammanfattning
Liver transplantation is a potentially a curative treatment for hepatocellular carcinoma, given that patients with limited tumor burden are selected. The Milan criteria from 1996 is the most widely accepted, indicating liver transplantation in cases with a single tumor of a maximum size of 5cm or no more than 3 tumors of 3cm or less. More liberal criteria have been tried, in order to increase the number of potentially curable patients, with acceptable long-term survival rates. In a Swedish patient cohort from 1996 to 2010, we analyzed how different extended selection tools, out of the Milan criteria, theoretically would affect the number of potentially cured patients in relation to the number of transplanted livers, and found the UCSF criteria (one single tumor =6,5 cm or =3 tumors =4,5 cm with a total tumor diameter of =8 cm) to be the most efficacious with an acceptable 5-year survival (63%).