Engelsk titel: Adverse childhood experiences and suicidal behavior
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Författare:
Brodsky, Beth S
;
Biggs, Emily
Språk: Eng
Antal referenser: 52
Dokumenttyp:
Översikt
UI-nummer: 13013351
Sammanfattning
Early experiences of physical and sexual abuse
are well-documented correlates of suicidal
behavior in adolescence and adulthood.
Childhood abuse and neglect have also been
reported as etiological factors in the development
of suicidal and self-harm behavior.
There is evidence that adverse childhood
experiences are related to the development
of certain personality traits that increase the
risk for suicidal behavior. Genetic and biological
studies of the relationship between
adverse childhood experiences and the serotonergic
system, the opioid receptor system,
and gene methylation identify possible biological
mediators between environmental
factors and personality traits related to suicidal
behavior. In this article we revisit and update
our 2008 review of what is known regarding
the relationship and mediators between childhood
abuse/neglect and suicidal behavior,
while giving emphasis to the most recent
findings. We integrate past and present
findings into a theoretical model that illustrate
current state of understanding as to how
childhood adversity and genetic/biological
factors interact to affect neurobiological
changes, which then lead to the development
of personality traits correlated with
suicidal behavior.