Varför vissa återfaller i alkoholberoende. Relation finns till en genvariant i dopaminsystemet och till psykologi
Engelsk titel: Why some people relapse in alcohol dependence. There is a relation to a specific gene variant in the dopamine system and to psychology
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Författare:
Balldin, Jan
;
Berggren, Ulf
;
Berglund, Kristina
;
Fahlke, Claudia
Email: claudia.fahlke@psy.gu.se
Språk: Swe
Antal referenser: 27
Dokumenttyp:
Översikt
UI-nummer: 13017857
Sammanfattning
The TaqIA polymorphism of the dopamine D2 receptor (DRD2) gene has been extensively studied in relation to alcoholism and the TaqI A1 allele appears to be over-represented in alcohol-dependent individuals. This allele has also been associated with a highly increased mortality rate in alcohol-dependent individuals. Moreover, we have recently found an association between the TaqI A1 allele and a substantially increased relapse rate. Other studies have shown that alcohol-dependent subjects who are carriers of the A1 allele have a diminished drinking refusal self-efficacy and show impairment in reversal learning situations. These findings indicate that alcohol-dependent individuals, who are carriers of the A1 allele, can benefit from more intense treatment, aimed to improve drinking refusal self-efficacy and relearning to focus on maintenance of abstinence.