Kateterbaserad renal denervering: ny metod vid resistent hypertoni. Betydande blodtrycksminskning, visar initiala erfarenheter av
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Sammanfattning
Despite access to a great variety of antihypertensive medication an estimated 30% of patients with hypertension do not meet target blood pressure. Renal sympathetic nerves are considered to be major contributors to systemic blood pressure control. Recently a catheter-based approach using radio-frequency ablation has been developed in order to disrupt efferent and afferent renal sympathetic nerve traffic. Two international multi-centre studies have demonstrated a high degree of patient safety and effective office blood pressure reduction up to 24 months after the procedure. During the period April 2011 – April 2012, 22 patients with resistant hypertension have been treated with renal sympathetic denervation at Sahlgrenska University Hospital, Gothenburg, Sweden. No periprocedural complications were noted. During follow up renal function was unaffected and no adverse events were documented. One month after renal denervation systolic and diastolic blood pressure was reduced by 22 mmHg (p<0.05) and 7 mmHg DBP (p<0.05) respectively. Renal nerve ablation appears to be a safe and effective technique in treatment of resistant hypertension. Future studies will reveal the true potential of renal denervation and define efficacy and benefit in specific patient groups.