Sammanfattning
Inclarity on dose adjustment in renal impairment
Kidney function should be regarded when dosing and prescribing. We assessed the prescribing information available in the Summary of Product Characteristics (SmPC) for the 253 drug substances on the Stockholm County Formulary for the year 2010 (a.k.a. “The Wise List”). More than half of the 253 drug substances (58%) were excreted by the kidneys by more than 20%. 61% of them had some remark or regarding renal function. Different eGFR methods were recommended for different drugs and clear definitions of the GFR limit for dose adjustment were often lacking. Future recommendations in the SmPCs should be improved on dose adjustment in renal impairment, e.g. clarifying which eGFR method to use and at what GFR the dose should be adjusted.