Olanzapin depot kan gi en tilstand forenlig med sentralt antikolinergt syndrom
Sammanfattning
Central anticholinergic syndrome can be life-threatening. The condition can occur as a result of unintended strong anticholinergic actions of a range of drugs. In rare cases, injection of olanzapine pamoate can give rise to a condition marked by delirium and sedation that is consistent with this syndrome. In cases of central anticholinergic syndrome, physostigmine is an effective antidote. Physostigmine is reported to give a good response in cases of oral overdose of olanzapine. Treatment with physostigmine should be considered if delirium and sedation occur following injection of olanzapine.