Engelsk titel: Long-term treatment with opioid drugs
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Författare:
Lindholm, Jörgen
;
Sjögren, Per
Email: rh12244@rh.regionh.dk
Språk: Dan
Antal referenser: 29
Dokumenttyp:
Översikt
UI-nummer: 14047882
Sammanfattning
It is well established that morphine and other opioid drugs in both men and women exert a pronounced effect on the gonads, causing hypogonadotroph hypogonadism. The thyroid function seems unimpaired. Only a small number of studies have addressed the effects of opioids on the adrenocortical function. They strongly suggest that opioids may cause adrenocortical insufficiency – even presenting as severe and life-threatening hypoadrenalism. At present a substantial number of patients are on long-term treatment with opioids, making the above findings relevant in daily clinical practice.