Mitokondriebyte - potentiell terapimetod med etiska implikationer. Svår sjukdom kan möjligen förhindras, men kunskapsluckor finns
Engelsk titel: Mitochondrial replacement - potential therapy method with ethical implications. Severe disease may be prevented, but knowledge
gaps exist
Läs online
Författare:
Wilbe Ramsay, Karin
;
Hanson, Charles
;
Asplund, Kjell
Email: karin.wilbe-ramsay@regeringskansliet.se
Språk: Swe
Antal referenser: 26
Dokumenttyp:
Översikt
UI-nummer: 14087172
Sammanfattning
Mitochondrial inherited disorders may cause severe disease, suffering and premature death. Today, there are no effective treatments available for the conditions. Novel techniques involving replacement of mutated mitochondria with mitochondria from healthy donors in association with IVF may provide a possibility to prevent children from inheriting the disorders. Recent research results from studies in primates and human cells have been reasonably promising. However, no baby has yet been born through the technique, and possible short and long term risks in humans are difficult to predict. Furthermore, the technique causes genetic alterations that are inherited, and thus raises fundamental ethical questions. The Swedish National Council on Medical Ethics has advised that mitochondrial replacement should not be used in humans in Sweden until more scientific knowledge is available.