Engelsk titel: Gastric carcinoma is the most frequent Epstein-Barr virus-associated malignancy
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Författare:
Boysen, Trine
;
Friborg, Jeppe
Email: jeppe.friborg@regionh.dk
Språk: Dan
Antal referenser: 30
Dokumenttyp:
Översikt
UI-nummer: 15017730
Sammanfattning
Epstein-Barr virus (EBV) is associated with 8% of gastric carcinomas (GC) worldwide, being the most frequent EBV-associated malignancy with 80,000 new cases per year. The association is based on the presence of clonal EBV products
in gastric tumour cells, and elevated EBV antibodies in prediagnostic sera. EBV-associated GC are twice as common in males and often associated to cancer in the cardia-region. Gastric surgery increases the risk significantly. Until now, no
clear interaction between Helicobacter pylori, the single most important risk factor for GC, and EBV has been established.