Hjärtamyloidos - tänkbar genes vid oklar diastolisk hjärtsvikt. Hypertroft myokardium och låga-normala QRS-komplex är karakteristiskt
Engelsk titel: Cardiac amyloidosis - possible etiology in unclear diastolic heart failure. Hypertrophic myocardium and low-normal QRS-amplitude is
characteristic
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Författare:
Labaf, Ashkan
;
Tasevska, Gordana
;
Ahlgren, Tomas
;
Stagmo, Martin
Email: ashkan.labaf@med.lu.se
Språk: Swe
Antal referenser: 30
Dokumenttyp:
Fallbeskrivning
UI-nummer: 15047002
Sammanfattning
Amyloidosis refers to a rare group of disorders, which can involve various organs. It is caused by extracellular deposition of insoluble
abnormal fibrils called amyloid. Cardiac amyloidosis in patients with AL-amyloidosis is common and associated with poor prognosis.
Characteristic symptoms are low voltage ECG, echocardiographic findings of hypertrophy, diastolic dysfunction and symptoms of right heart
failure. We present a 51 year-old patient with dyspnea and chest pain and recurring pleura effusions. ECG showed T-wave inversions in the
lateral and inferior leads with normal QRS-amplitude and first echocardiography showed moderate concentric hypertrophy left ventricle,
moderate enlarged atria and a restrictive diastolic filling pattern. The coronary angiography was normal. The diagnosis was delayed for
several months and the symptoms worsened. Physicians must be aware of amyloidosis and other infiltrative cardiomyopathies as
differential diagnosis in patients with unclear diastolic dysfunction even with normal QRS-amplitude.