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Forebyggelse af skeletrelaterede haendelser hos patienter med knoglemetastaser ved solide tumorer
Engelsk titel: Prevention of skeletal related events in patients with bone metastases from solid tumours Läs online Författare: Kamby, Claus ; Tarp, Simon ; Mellemgaard, Anders ; Christensen, Robin ; Cold, Sören ; Eiken, Pia ; Hugger Jakobsen, Erik ; Langkilde, Niels Christian ; Langkjer, Sven Tyge ; Laursen, Torben ; Saalbach Ottesen, Svend ; Gorm Pedersen, Anita ; Stenbygaard, Lars Eric ; Vestlev, Peter Michael Språk: Dan Antal referenser: 30 Dokumenttyp: Översikt UI-nummer: 15057197

Tidskrift

Ugeskrift for Laeger 2015;177(7)645-8 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

This article is based on a systematic literature search and meta-analyses of clinical data regarding effects of bisphosphonates (BP) and denosumab (DS) on preventing skeletal related events (SRE) in patients with bone metastases from solid tumours. Although there are pharmacological differences between the different types of BP no major differences were observed between BP in preventing SRE or in adverse events. Treatment with DS has in three randomised trials showed a greater effect than BP in preventing SRE. The optimal choice of bone-anti-resorptive agent should depend on the patient’s general condition, renal function and treatment logistics.