Forebyggelse af skeletrelaterede haendelser hos patienter med knoglemetastaser ved solide tumorer
Engelsk titel: Prevention of skeletal related events in patients with bone metastases from solid tumours
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Författare:
Kamby, Claus
;
Tarp, Simon
;
Mellemgaard, Anders
;
Christensen, Robin
;
Cold, Sören
;
Eiken, Pia
;
Hugger Jakobsen, Erik
;
Langkilde, Niels Christian
;
Langkjer, Sven Tyge
;
Laursen, Torben
;
Saalbach Ottesen, Svend
;
Gorm Pedersen, Anita
;
Stenbygaard, Lars Eric
;
Vestlev, Peter Michael
Email: claus.kamby@regionh.dk
Språk: Dan
Antal referenser: 30
Dokumenttyp:
Översikt
UI-nummer: 15057197
Sammanfattning
This article is based on a systematic literature search and meta-analyses of clinical data regarding effects of bisphosphonates (BP) and denosumab (DS) on preventing skeletal related events (SRE) in patients with
bone metastases from solid tumours. Although there are pharmacological differences between the different types of BP no major differences were observed between BP in preventing SRE or in adverse events. Treatment
with DS has in three randomised trials showed a greater effect than BP in preventing SRE. The optimal choice of bone-anti-resorptive agent should depend on the patient’s general condition, renal function and treatment
logistics.